Raffaele Colombo· @raffcolo · X·· 2 天前评分70
正文 · 机器翻译
令人费解的是，Mo-Rez 应答者中出现了组织蛋白酶 B（CTSB）富集，因为 GGFG 连接肽是组织蛋白酶 L 的底物，而非组织蛋白酶 B 的底物。
至少也应该纳入 CTSL。
#ESMO26
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- Dennis Kwiatkowski@KwiatBerlin
@raffcolo True, but CTSB can cleave this sequence - leaving glycin-exatecan (evident with DE-310), which should however be less potent than free exatecan released from CTSL. Given that both CTSL and CTsB are expressed in PROC I guess you have a mixture of cleaved payloads.
来源：Raffaele Colombo · x.com