Raffaele Colombo· @raffcolo · X·· 2 天前评分70
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Puzzling to see cathepsin B (CTSB) enrichment in Mo-Rez responders, given that the GGFG linker is a substrate of cathepsin L, not B.
CTSL should have been included at a minimum.
#ESMO26
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- Dennis Kwiatkowski@KwiatBerlin
@raffcolo True, but CTSB can cleave this sequence - leaving glycin-exatecan (evident with DE-310), which should however be less potent than free exatecan released from CTSL. Given that both CTSL and CTsB are expressed in PROC I guess you have a mixture of cleaved payloads.
来源：Raffaele Colombo · x.com