Skip to content
Back to meeting Original
Raffaele Colombo· @raffcolo · X·· 2 days agoScore70
Body

Puzzling to see cathepsin B (CTSB) enrichment in Mo-Rez responders, given that the GGFG linker is a substrate of cathepsin L, not B.

CTSL should have been included at a minimum.

#ESMO26

240 views · 6 likes · 3 reposts · 1 reply

Replies in this thread
  1. Dennis Kwiatkowski@KwiatBerlin

    @raffcolo True, but CTSB can cleave this sequence - leaving glycin-exatecan (evident with DE-310), which should however be less potent than free exatecan released from CTSL. Given that both CTSL and CTsB are expressed in PROC I guess you have a mixture of cleaved payloads.

Source: Raffaele Colombo · x.com

CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org

Disclaimer CBA Frontier Insights uses AI-assisted methods to aggregate, summarize, and analyze publicly accessible biopharmaceutical information. Content is provided for informational and educational purposes only and does not represent the official views of original sources or affiliated organizations. AI-generated content may contain errors; please verify important information against primary sources. Intellectual property rights remain with their respective owners. For copyright concerns or corrections, please contact us through the website’s feedback page.