ESMO 2026: BXP-001 Plus Radiotherapy Extends Progression-Free Survival in iNATURE Trial
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At ESMO 2026 in Madrid, researchers presented phase 2/3 results from the iNATURE randomized controlled trial, showing that BXP-001 combined with radiotherapy significantly extended progression-free survival in patients with advanced tumors. The trial was co-sponsored by Genvoy Bio/Bay Bio and the University of Hong Kong-Shenzhen Hospital, and the results were delivered on October 24, 2026 as rapid oral and poster presentations. The sponsor also reports notable efficacy in preventing post-surgical recurrence. Key quantitative details, including median progression-free survival, sample size and hazard ratio, have not been disclosed, and fuller data and any path toward registration remain open questions. The same congress also brought ADC-focused news from GSK, whose oncology R&D head said fresh data reinforced confidence in its ADC as phase 3 development ramps up.
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The Phase III PANKU-Lung01 trial of iza-bren (BL-B01D1) met its primary PFS endpoint in advanced NSCLC resistant to EGFR-TKIs and was selected as an LBA at the 2026 ESMO Congress, with data due on the 26th. Historical platinum-based doublet chemotherapy achieved an ORR of about 30% and median PFS of 4 to 5 months, while the cited Phase II monotherapy data for iza-bren showed an ORR of 66.0% and median PFS of 12.5 months.
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The 2026 ESMO congress includes six mirvetuximab soravtansine (MIRV) abstracts, covering a post hoc analysis of first-line therapy and responders in FRα-positive platinum-resistant ovarian cancer, long-term follow-up from Chinese real-world data, pretreatment albumin as a predictor, the FLORENZA combination regimen, and hematologic safety of carboplatin combination in platinum-sensitive ovarian cancer.
- mp.weixin.qq.comESMO 2026: BXP-001 Plus Radiotherapy Significantly Extends Progression-Free Survival in iNATURE Advanced Tumor Randomized Trial
The iNATURE trial, presented at ESMO 2026, showed that BXP-001 combined with radiotherapy significantly extended progression-free survival in a randomized controlled study of advanced tumors. The trial was co-sponsored by Genvoy Bio/Bay Bio and the University of Hong Kong-Shenzhen Hospital, with the phase 2/3 results presented as rapid oral and poster presentations in Madrid, Spain on October 24, 2026. The original report also claims notable efficacy in post-surgical recurrence prevention, but lists no specific PFS figures, sample size, or hazard ratio.
- news.google.comESMO: GSK cancer R&D chief says mo-rez data ‘reinforces our belief’ in ADC as phase 3 push ramps up - Fierce Biotech
At ESMO, GSK's head of oncology R&D said the mo-rez data reinforce confidence in the ADC as phase 3 development accelerates.
- news.google.comESMO 2026 - Fierce Biotech
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ESMO 2026 published abstracts from three advanced HCC studies. Phase I updates for C-CAR031 and BGB-B2033 showed preliminary antitumor activity, while the long-term LEAP-012 analysis showed no OS benefit. C-CAR031 achieved an ORR of 44% and DCR of 92% in 36 patients, with tumor lysis syndrome-related deaths and interstitial lung disease reported; confirmed ORR across BGB-B2033 dose groups in 110 patients ranged from 16.0% to 35.7%, and 450 mg was selected as the recommended phase II dose.
- mp.weixin.qq.comESMO 2026: Professor Huang Jun Interprets the CRIT Precision-Targeted Neoadjuvant Study in Locally Advanced Rectal Cancer
At ESMO 2026, Professor Huang Jun presented the CRIT phase 2 study, in which 49 patients with high-risk pMMR/MSS locally advanced rectal cancer achieved an overall pathological complete response (pCR) rate of 51.1%. Treatment was selected by RAS/BRAF status, using cetuximab beta or bevacizumab; pCR rates were 57.1% in the wild-type subgroup and 46.2% in the mutant subgroup. Of 47 patients who underwent surgery, 24 achieved pCR, and the R0 resection rate was 100%.
- mp.weixin.qq.comChia Tai Tianqing Reports Phase III Results for TQB2102 in HER2-Low Breast Cancer at ESMO
Chia Tai Tianqing, a core subsidiary of Sino Biopharmaceutical, reported pivotal Phase III results for its independently developed TQB2102 in HER2-low breast cancer, selected as a late-breaking abstract for a proffered paper session at ESMO. The abstract showed a median progression-free survival of 16.4 months with TQB2102 versus 5.5 months with comparator chemotherapy, an approximately 71% reduction in risk of disease progression or death, and a 2.2% incidence of treatment-related ILD.
- mp.weixin.qq.comESMO 2026 Chinese Orals: Dual TKI Improves MET-Amplified Resistance, CS2009 and Ivonescimab Report NSCLC and Thymic Carcinoma Data
Three Chinese-led oral presentations at ESMO 2026 updated data on MET-amplification resistance, NSCLC, and thymic carcinoma. A dual-TKI regimen significantly improved PFS in a randomized phase 3 study: NCT06110663 randomized 314 patients, with IRC-assessed mPFS of 6.2 vs 4.4 months, HR 0.601, P<0.001. CS2009 showed a preliminary ORR/DCR of 81.3%/100% in the evaluable first-line PD-L1 TPS≥50% population.
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- mp.weixin.qq.comOptiTROP-Lung04 Final OS Analysis to Report at ESMO 2026 in EGFR-TKI-Resistant NSCLC
Experts review survival data for sacituzumab tirumotecan in EGFR-TKI-resistant NSCLC. The final overall survival analysis of OptiTROP-Lung04 will be presented at ESMO 2026.
- mp.weixin.qq.comPick2026 ESMO Preview: Pimicotinib MANEUVER 2-Year TGCT Follow-Up and Three Nirogacestat Desmoid Tumor Datasets
Five studies from Merck KGaA's pimicotinib and nirogacestat were accepted for the 2026 ESMO congress, covering long-term follow-up and quality of life in TGCT, as well as dose-reduction, real-world, and indirect comparison evidence in desmoid tumors.
- zhitongcaijing.comPickHenlius Serplulimab ASTRIDE US Bridging Data to Be Presented Orally at ESMO 2026
Henlius released the ASTRIDE abstract at ESMO 2026. The US head-to-head bridging study will be presented as an oral report on serplulimab versus atezolizumab, both with chemotherapy, as first-line treatment for ES-SCLC. At a median follow-up of 14.1 months, median OS was 12.4 months with serplulimab versus 10.2 months with atezolizumab; 24-month OS rates were 32.2% and 17.6%. Safety was generally comparable between groups with no new safety signals; HANSIZHUANG had 10 studies accepted at the congress.
- mp.weixin.qq.comPickESMO 2026: Qilu's QL1706 Posts 30.95-Month OS in Phase 3 First-Line Cervical Cancer
At ESMO 2026, Qilu Pharmaceutical reported phase 3 overall survival of 30.95 months for QL1706, a PD-1/CTLA-4 bispecific antibody, plus chemotherapy with or without bevacizumab as first-line treatment of persistent, recurrent or metastatic cervical cancer.
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Heat now 88·Peak in the comparable set 140 (Oct 24 20:00)·Change over 24h in the comparable set -14%·Participants now 37
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