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AACR 2026 年会

2026 年 4 月 17–22 日 · San Diego · 共 2429 条

← KRAS / RAS 靶向 — 从平台化到 Ph3 验证

#PDAC

临床试验

4 人 · 5 条 · 3 篇摘要

记录
药 / 试验读数场景
daraxonrasib ± GnPdaraxonrasib#PANCREATICCANCER#PDAC单药 ORR 47%;联合 ORR 55%,DCR 90%1L mPDAC · Ph1
其他对照
  • daraxonrasibmOS 13.2 vs 6.7 月,HR 0.40
  • zoldonrasibORR 52%,DCR 93%,mPFS 11.1 月;ctDNA 清除 73%
  • VS-7375NSCLC ORR 68.8%(n=16);胰腺 ORR 58%
  • elisrasib未治 G12C NSCLC ORR 59.5%;经治 32.3%
  • RM-055在 daraxonrasib 耐药和 RAS 扩增模型里有抗肿瘤活性
证据
Safety and efficacy of Elisrasib (D3S-001), a next generation GDP-bound KRAS G12C inhibitor, as monotherapy or combination therapy with cetuximab in previously treated metastatic CRC and PDAC: Results from a phase 1/2 study

Kanwal Pratap Raghav, Jun Zhang, Myung-Ah Lee, Jingdong Zhang, John Park, Yanqiao Zhang, Susana Rosello Keranen, Byoung Chul Cho, Herbert Ho Fung Loong, Cheng Chen, Huan Li, Shaonan Wang, Yandong Shen, Zifei Fan, Qian Chen, Hui Wang, Jing Zhang, George Zhi Jian Chen, Jayesh Desai, Antoine Hollebecque

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Daraxonrasib plus chemotherapy (CT) as first-line (1L) treatment for patients (Pts) with metastatic pancreatic adenocarcinoma (mPDAC)

Brian M. Wolpin, Benjamin L. Musher, Gulam A. Manji, Wungki Park, Alexander Spira, Nilofer Azad, Vaia Florou, Tiago Biachi De Castria, Mark H. O'Hara, Erkut Borazanci, Aparna Parikh, John Strickler, Joel Randolph Hecht, Shubham Pant, Shiraj Sen, E. Gabriela Chiorean, W. Clay Gustafson, Hina Patel, Vidya Seshadri, Yan Zheng, Davendra Sohal

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现场
4月22日周三
4月21日周二
4月20日周一
CBACBA Frontier Insights (CFI)美国华人生物医药科技协会(CBA)www.cba-usa.org