Kanwal Pratap Raghav, Jun Zhang, Myung-Ah Lee, Jingdong Zhang, John Park, Yanqiao Zhang, Susana Rosello Keranen, Byoung Chul Cho, Herbert Ho Fung Loong, Cheng Chen, Huan Li, Shaonan Wang, Yandong Shen, Zifei Fan, Qian Chen, Hui Wang, Jing Zhang, George Zhi Jian Chen, Jayesh Desai, Antoine Hollebecque
读摘要原文 →
AACR 2026 年会
2026 年 4 月 17–22 日 · San Diego · 共 2429 条
← KRAS / RAS 靶向 — 从平台化到 Ph3 验证
#PDAC
临床试验4 人 · 5 条 · 3 篇摘要
记录
| 药 / 试验 | 读数 | 场景 |
|---|---|---|
| daraxonrasib ± GnPdaraxonrasib#PANCREATICCANCER#PDAC | 单药 ORR 47%;联合 ORR 55%,DCR 90% | 1L mPDAC · Ph1 |
其他对照
- daraxonrasibmOS 13.2 vs 6.7 月,HR 0.40
- zoldonrasibORR 52%,DCR 93%,mPFS 11.1 月;ctDNA 清除 73%
- VS-7375NSCLC ORR 68.8%(n=16);胰腺 ORR 58%
- elisrasib未治 G12C NSCLC ORR 59.5%;经治 32.3%
- RM-055在 daraxonrasib 耐药和 RAS 扩增模型里有抗肿瘤活性
证据
CT303NCT05410145
Safety and efficacy of Elisrasib (D3S-001), a next generation GDP-bound KRAS G12C inhibitor, as monotherapy or combination therapy with cetuximab in previously treated metastatic CRC and PDAC: Results from a phase 1/2 studyLB337NCT05379985
Daraxonrasib monotherapy as first-line (1L) treatment for patients with metastatic pancreatic adenocarcinoma (mPDAC)Eileen M. O'Reilly, Brian Wolpin, Shubham Pant, Joel Randolph Hecht, Jennifer Valerin, Dae Won Kim, Nilofer Azad, Kyaw Aung, Lin Tao, Sumit Kar, Hina Patel, Rashmi Vora, Aparna Hegde, Alexander Spira, Alexander Starodub, Benjamin Herzberg, Ignacio Garrido-Laguna
读摘要原文 →Brian M. Wolpin, Benjamin L. Musher, Gulam A. Manji, Wungki Park, Alexander Spira, Nilofer Azad, Vaia Florou, Tiago Biachi De Castria, Mark H. O'Hara, Erkut Borazanci, Aparna Parikh, John Strickler, Joel Randolph Hecht, Shubham Pant, Shiraj Sen, E. Gabriela Chiorean, W. Clay Gustafson, Hina Patel, Vidya Seshadri, Yan Zheng, Davendra Sohal
读摘要原文 →现场
AACR 2026 现场信号@评分6060 AACR 2026 现场信号@评分6060
Cancer Research@CR_AACR评分6060 Cancer Research@CR_AACR评分6060