bioRxiv Cancer Biology· Ishihara, M. A., M. Moro Valeriano, M., Oliveira, N., Mamede, I., Cavalcanti de Morais Gama, L., Ferreira Cunha, A., Maia Santos de Castro, I., Vasquez, F., Nishiyama-Jr, M. Y., Setubal, J. C., de Arruda Neto, E., Chammas, R., Nakaya, H. I. ·· 14 小时前评分35
HPV16与HPV18宫颈癌的多尺度转录特征：宿主通路差异及病毒基因表达程序的关联
Multi-scale Transcriptional Characterization of HPV16 and HPV18 in Cervical Cancer: Host Pathway Alterations and Links With Viral Gene Expression Programs
导读
研究在两个独立队列（n=93；76例HPV16、17例HPV18）中联合分析病毒与宿主基因表达，发现两型宫颈癌宿主转录程序存在差异。55基因签名可区分两型；HPV16富集上皮极性与RTK-RAS-MAPK信号并伴CDX2 regulon异常活化，HPV18呈代谢重编程与STAT3/HIF1A相关炎症信号。
来源：bioRxiv Cancer Biology · biorxiv.org