柳叶刀· Tamara J Oderkerk, Jaklien C Leemans, Pleun Beelen, Malou C Herman, Sjors F P J Coppus, Marijke C van der Weide, Sander M J Van Kuijk, Thomas J Clark, Marlies Y Bongers, Peggy M A J Geomini, MIRA2 study group·· 3 小时前精选评分57
MIRA2试验：荷兰月经过多女性中，子宫内膜消融联合左炔诺孕酮释放宫内系统较单独消融降低子宫切除发生率
[Articles] Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial
导读
MIRA2在荷兰开展的多中心、开放标签、随机对照优效试验显示，子宫内膜消融联合左炔诺孕酮释放宫内系统可降低月经过多女性的子宫切除发生率，优于单独子宫内膜消融。联合治疗似乎可作为安全的辅助策略，且未增加并发症风险。
推荐理由
MIRA2随机对照试验在同一消融基础上比较加用左炔诺孕酮宫内系统与否，显示联合治疗降低子宫切除发生率且未增加并发症风险。
来源：柳叶刀 · thelancet.com