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AACR 2026 现场信号· @ · X·· 2026-04-23评分60

#MELANOMA

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免疫治疗前沿 — CAR-T 实体瘤、mRNA 疫苗、TCR-T

mRNA-4157 · 黑色素瘤无复发生存 HR 0.44

正文 · 机器翻译

@SU2C 的长期合作伙伴、来自 @UCLAHealthJCCC 的 Antoni Ribas 博士于周二在 @AACR AM 2026 上发表演讲。Ribas 博士主持了一场关于 #melanoma 研究的分会,并介绍了针对耐药黑色素瘤的新策略。#AACR26 https://t.co/NCoZEx3xpH

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会议摘要
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NRX-0305, an orally bioavailable, CNS penetrant pan-mutant BRAF degrader demonstrates robust efficacy in intracranial models of melanoma brain metastasis and primary glioma

Alexandra Borodovsky, Ya-Wen Lu, Ge Peng, Karthik Arumugam, Paul L. Auger, Delia Bradford, Lilly G. Carlson, Scott K. Kimura, Daniel Medina-Cleghorn, Mariah J. Mesner, Davorka Messmer, Madeleine P. Nemchek, Ryan B. Rountree, Rusha M. Sardhara, Sangita Sridharan, Jennifer M. Stokes, Leslie Tong, Alexandra M. Trotier, Jennifer S. Tung, Ge Wei, Jeffrey Wu, Jordan Ye, Gwenn M. Hansen

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CT238NCT02706353按 药名 sotigalimab 对上
Intratumoral sotigalimab with pembrolizumab induces rapid activation of antigen presenting cells and drives anti-tumor responses in non-injected tumors in metastatic melanoma: A phase I/II study

Salah-Eddine Bentebibel, Daniel J McGrail, Veena Kochat, Emre Arslan, Reham Abdel-Wahab, Sung-Nam Cho, Xiaodong Yang, Daniel H Johnson, Rodabe N Amaria, Isabella C Glitza, Patrick Hwu, Hussein A Tawbi, Jared K Burks, Michael A Davies, Kunal Rai, Suhendan Ekmekcioglu, Adi Diab

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来源:AACR 2026 现场信号 · x.com

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