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#MELANOMA

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Immunotherapy: CAR-T in solid tumors, mRNA vaccines, TCR-T

mRNA-4157 · Melanoma RFS HR 0.44

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Longtime @SU2C-collaborator Dr. Antoni Ribas from @UCLAHealthJCCC presented on Tuesday at @AACR AM 2026. Dr. Ribas chaired a session on #melanoma research and presented on new strategies for targeting resistant melanomas. #AACR26 https://t.co/NCoZEx3xpH

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Conference abstracts
4617matched by 代号 NRX-0305
NRX-0305, an orally bioavailable, CNS penetrant pan-mutant BRAF degrader demonstrates robust efficacy in intracranial models of melanoma brain metastasis and primary glioma

Alexandra Borodovsky, Ya-Wen Lu, Ge Peng, Karthik Arumugam, Paul L. Auger, Delia Bradford, Lilly G. Carlson, Scott K. Kimura, Daniel Medina-Cleghorn, Mariah J. Mesner, Davorka Messmer, Madeleine P. Nemchek, Ryan B. Rountree, Rusha M. Sardhara, Sangita Sridharan, Jennifer M. Stokes, Leslie Tong, Alexandra M. Trotier, Jennifer S. Tung, Ge Wei, Jeffrey Wu, Jordan Ye, Gwenn M. Hansen

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CT238NCT02706353matched by 药名 sotigalimab
Intratumoral sotigalimab with pembrolizumab induces rapid activation of antigen presenting cells and drives anti-tumor responses in non-injected tumors in metastatic melanoma: A phase I/II study

Salah-Eddine Bentebibel, Daniel J McGrail, Veena Kochat, Emre Arslan, Reham Abdel-Wahab, Sung-Nam Cho, Xiaodong Yang, Daniel H Johnson, Rodabe N Amaria, Isabella C Glitza, Patrick Hwu, Hussein A Tawbi, Jared K Burks, Michael A Davies, Kunal Rai, Suhendan Ekmekcioglu, Adi Diab

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