Longtime @SU2C-collaborator Dr. Antoni Ribas from @UCLAHealthJCCC presented on Tuesday at @AACR AM 2026. Dr. Ribas chaired a session on #...

返回会议原文

返回会议

AACR 2026 现场信号· @ · X·2026-04-23 00:52· 2026-04-23评分60

#MELANOMA

解读

免疫治疗前沿 — CAR-T 实体瘤、mRNA 疫苗、TCR-T

mRNA-4157 · 黑色素瘤无复发生存 HR 0.44

正文 · 原文

Longtime @SU2C-collaborator Dr. Antoni Ribas from @UCLAHealthJCCC presented on Tuesday at @AACR AM 2026. Dr. Ribas chaired a session on #melanoma research and presented on new strategies for targeting resistant melanomas. #AACR26 https://t.co/NCoZEx3xpH

热度 9 · 7 赞 · 0 回复 · 2 转发

会议摘要

1554按药名 irinotecan 对上

Combining an optimized irinotecan formulation with self-amplyfing RNA to treat an immunosuppressive lung metastasis melanoma model

XuXin Sun, Nasim Sarrami, Irafasha C. Casmil, Sijie Zhang, Marcel B. Bally, Anna K. Blakney

读摘要原文 →

4617按代号 NRX-0305 对上

NRX-0305, an orally bioavailable, CNS penetrant pan-mutant BRAF degrader demonstrates robust efficacy in intracranial models of melanoma brain metastasis and primary glioma

Alexandra Borodovsky, Ya-Wen Lu, Ge Peng, Karthik Arumugam, Paul L. Auger, Delia Bradford, Lilly G. Carlson, Scott K. Kimura, Daniel Medina-Cleghorn, Mariah J. Mesner, Davorka Messmer, Madeleine P. Nemchek, Ryan B. Rountree, Rusha M. Sardhara, Sangita Sridharan, Jennifer M. Stokes, Leslie Tong, Alexandra M. Trotier, Jennifer S. Tung, Ge Wei, Jeffrey Wu, Jordan Ye, Gwenn M. Hansen

读摘要原文 →

CT238NCT02706353按药名 sotigalimab 对上

Intratumoral sotigalimab with pembrolizumab induces rapid activation of antigen presenting cells and drives anti-tumor responses in non-injected tumors in metastatic melanoma: A phase I/II study

Salah-Eddine Bentebibel, Daniel J McGrail, Veena Kochat, Emre Arslan, Reham Abdel-Wahab, Sung-Nam Cho, Xiaodong Yang, Daniel H Johnson, Rodabe N Amaria, Isabella C Glitza, Patrick Hwu, Hussein A Tawbi, Jared K Burks, Michael A Davies, Kunal Rai, Suhendan Ekmekcioglu, Adi Diab

读摘要原文 →

来源：AACR 2026 现场信号 · x.com