bioRxiv Cancer Biology· Krishnamoorthy, V., Gupta, V. K., Jinka, S., Srinivasan, S., M, K. H., Shi, C., Poorva, P., Chen, S. X., Merchant, N., Dosch, A. R., Nagathihalli, N. ·· 14 小时前评分42
烟草致癌物NNK在胰腺导管癌变中诱导持续性DNA损伤与同源重组修复失调
Tobacco Carcinogen Induces Persistent DNA Damage and Homologous Recombination Dysregulation in Pancreatic Ductal Carcinogenesis
导读
烟草致癌物NNK慢性暴露可致胰腺导管上皮细胞持续DNA损伤与同源重组修复失调，引发染色体不稳定。5天急性暴露激活ATM-γH2AX依赖性HR修复，50天慢性暴露则出现RAD51、BRCA1/2、FANCD2、PLK1转录上调但修复保真度下降。γH2AX在NNK处理细胞、KRAS驱动癌前病变及吸烟者胰腺组织中显著升高，与PDAC患者肿瘤进展和不良预后相关。
来源：bioRxiv Cancer Biology · biorxiv.org