APEX-BREAST01
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Chia Tai Tianqing presented APEX-Breast01 results for TQB2102 at ESMO 2026, showing it significantly improved median progression-free survival (mPFS) over chemotherapy in patients with HER2-low advanced breast cancer. TQB2102, a next-generation HER2 bispecific ADC, achieved an mPFS of 16.4 months versus 5.5 months with chemotherapy, a 71% reduction in the risk of disease progression or death, with treatment-related interstitial lung disease (ILD) occurring in 2.2% of patients.
Excerpted from mp.weixin.qq.com
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- mp.weixin.qq.comPickChia Tai Tianqing's TQB2102 Cuts Progression or Death Risk 71% Versus Chemotherapy in APEX-Breast01 in HER2-Low Advanced Breast Cancer
Chia Tai Tianqing presented APEX-Breast01 results for TQB2102 at ESMO 2026, showing it significantly improved median progression-free survival (mPFS) over chemotherapy in patients with HER2-low advanced breast cancer. TQB2102, a next-generation HER2 bispecific ADC, achieved an mPFS of 16.4 months versus 5.5 months with chemotherapy, a 71% reduction in the risk of disease progression or death, with treatment-related interstitial lung disease (ILD) occurring in 2.2% of patients.
- mp.weixin.qq.comSino Biopharmaceutical's TQB2102 Shows 16.4-Month PFS and 2.2% ILD in Phase III HER2-Low Breast Cancer
Sino Biopharmaceutical's TQB2102 met its primary endpoint in the phase III APEX-Breast01 study in HER2-low recurrent or metastatic breast cancer. In the HR+/HER2-low population, median PFS was 16.4 months versus 5.5 months with chemotherapy, with a hazard ratio of 0.29 (p<0.0001) and an ILD incidence of only 2.2%.
- mp.weixin.qq.comPickCTTQ Reports Phase II First-Line Data for TQB2102 Plus Benmelstobart and Capecitabine in HER2-Positive Advanced Gastric Cancer at ESMO, Triplet ORR 84.2%
Chia Tai Tianqing (CTTQ) presented Phase II results at ESMO 2026 for TQB2102 combined with benmelstobart and capecitabine as first-line therapy for HER2-positive advanced gastric cancer, with the triplet regimen achieving an ORR of 84.2%. As of September 3, 2026, the TQB2102-II-04 study (NCT06767800) had enrolled 86 patients; the 6 mg/kg triplet arm showed an ORR of 95.8% (23/24), a cORR of 91.7% and a DCR of 100%, and this dose was selected as the recommended dose for the subsequent Phase III study.
- mp.weixin.qq.comESMO 2026: TQB2102 Phase III APEX-Breast01 Shows PFS Improvement Over Chemotherapy in HER2-Low Breast Cancer
The Phase III APEX-Breast01 study of TQB2102, presented at ESMO 2026, showed significantly prolonged PFS versus investigator's choice chemotherapy in patients with HER2-low breast cancer. The study enrolled patients with HER2-low breast cancer at the recurrent or metastatic stage who had not previously received chemotherapy. TQB2102 is a HER2 bispecific epitope antibody-drug conjugate.
- mp.weixin.qq.comChia Tai Tianeeng TQB2102 Cuts Risk of Progression or Death by 71% in HER2-Low Advanced Breast Cancer in APEX-Breast01 Phase 3
At ESMO 2026, Chia Tai Tianeeng presented randomized phase 3 data for TQB2102, a HER2 dual-epitope ADC, from the APEX-Breast01 trial. In HER2-low advanced breast cancer, TQB2102 reduced the risk of disease progression or death by 71% compared with chemotherapy.
- mp.weixin.qq.comPickSino Biopharmaceutical's TQB2102 Extends Median PFS to 16.4 Months in Phase 3 HER2-Low Breast Cancer Study
Sino Biopharmaceutical presented phase 3 results for TQB2102 in HER2-low breast cancer at ESMO 2026: median progression-free survival was 16.4 months versus 5.5 months in the chemotherapy arm. APEX-Breast01 was released as LBA27, with 543 patients randomized as of May 31, 2026; HR was 0.29 in both the HR+/HER2-low population and the overall HER2-low population, with 95% CIs of 0.22–0.39 and 0.22–0.38, respectively, and p<0.0001.
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Heat now 47·Peak in the comparable set 90 (Oct 24 09:00)·Change over 24h in the comparable set -43%·Participants now 14
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