AACR Annual Meeting 2026

April 17–22, 2026 · San Diego · 2418 items

← Lung cancer: perioperative IO and KRAS NSCLC

EGFR

14 people · 15 posts · 2 abstracts

Heat trend for this story

Heat now 4·Peak in the comparable set 4 (Apr 23 01:00)·Change over 24h in the comparable set –·Participants now 6

Participants counted6

Heat over time

Participants counted above, heat below. The trend compares only the participants observed in full throughout, so its set can be smaller than the heat figure itself. Move the pointer or click the chart for an hour's reading; the left and right arrow keys work too.

Sherlock-Lung’s 1,209 whole genomes: EGFR more often in never-smokers, KRAS more often in smokers.

Records

Drug / trial	Readout	Setting
LCINS / Sherlock-LungEGFR KRAS #LUNGCANCER	1,209 WGS: EGFR in never-smokers, KRAS in smokers	A separate-disease frame

Other cases in this chapter

adebrelimabPerioperative EFS HR 0.52
taletrectinibROS1+ ORR 90%, DoR 49.7 mo
CheckMate 77THigh pCR only in ctDNA clearers

Evidence

2968

EGFR S442 mutation confers cetuximab resistance that can be overcome by ERBB2 blockade by trastuzumab-deruxtecan.

Neeraj Joshi, Sarah J. Harmych, Hidenori Tanaka, Galina Bogatcheva, Marisol A. Ramirez, Ramona Graves-Deal, Claiborne W. Tydings, Claudia C. Wahoski, Chelsie K. Sievers, Maria Johnson Irudayam, James N. Higginbotham, Frank L. Revetta, Zhiguo Zhao, Jeffrey L. Franklin, Binyam Yilma, Tina M. O'Grady, Stamatina Fragkogianni, Metamia Ciampricotti, M Kay Washington, Xingyi Guo, Allison S. Walker, Jens Meiler, Qi Liu, Robert J. Coffey, Eben L. Rosenthal, Bhuminder Singh

Read the abstract →

5801

NRX-0305 is an orally bioavailable, pan-mutant BRAF degrader that exhibits single-agent and combination efficacy with MEKi or anti-EGFR across Class 1/2/3 BRAF-mutant cancers

Ya-Wen Lu, Alexandra Borodovsky, Ge Peng, Karthik Arumugam, Paul L. Auger, Delia Bradford, Lilly G. Carlson, Scott K. Kimura, Daniel Medina-Cleghorn, Mariah J. Mesner, Davorka Messmer, Madeleine P. Nemchek, Ryan B. Rountree, Rusha M. Sardhara, Sangita Sridharan, Jennifer M. Stokes, Leslie Tong, Alexandra M. Trotier, Jennifer S. Tung, Ge Wei, Jeffrey Wu, Jordan Ye, Gwenn M. Hansen.

Read the abstract →

Floor

Apr 23Thu

Thursday · 2 items

02:09
x.com@Score6060
Super interesting poster at #AACR26 by @BobakParang from @OSUCCC_James
Same topic EGFR · 14 people #EGFR #NSCLCHeat 106 likes1 reply3 reposts
00:30
x.com@Score6060
Great job Mimansa at #AACR26 presenting our work on therapeutic targeting of ART1 in EGFR mutated NSCLC. We are excited about this target...
Same topic EGFR · 14 peopleHeat 2520 likes0 replies5 reposts

Apr 22Wed

Wednesday · 6 items

23:01
x.com@Score6060
Check out "Clinical and molecular characterization of a rare EGFR cis compound L833V/H835L mutation in non-small cell lung cancer" from Y...
Same topic EGFR · 14 peopleHeat 00 likes0 replies0 reposts
22:49
x.com@Score6060
At #AACR26, Lixing Yang, PhD, presents genomic data from 1,209 lung cancer patients, showing distinct patterns of somatic structural vari...
Same topic EGFR · 14 people KRASHeat 159 likes1 reply5 reposts
07:12
x.com@Score6060
Research presented by Mariana Do Carmo @yalepathology shows tumor suppressor gene loss plays a major role in how EGFR-mutant #lungcancer ...
Same topic EGFR · 14 people #LUNGCANCERHeat 1914 likes0 replies5 reposts
06:51
x.com@Score6060
At #AACR26, Living Yang, PhD, presents genomic data from 1,209 lung cancer patients, showing distinct patterns of somatic structural vari...
Same topic EGFR · 14 people KRASHeat 63 likes1 reply2 reposts
04:20
x.com@Score6060
Finally, we have the discovery of a resistance mechanism.
Same topic EGFR · 14 people #HIFISEQUENCINGHeat 1914 likes0 replies5 reposts
01:59
x.com@Score6060
Congratulations to Yen-Ting Lin and colleagues on their simultaneous publication—Mechanisms of Acquired Resistance Following Dual EGFR/ME...
Same topic EGFR · 14 people METHeat 22 likes0 replies0 reposts

Apr 21Tue

Tuesday · 3 items

06:05
LUNGevity Foundation@LUNGevityScore6060
@TakashiKohno2
Same topic EGFR · 14 peopleHeat 11 like0 replies0 reposts
06:02
LUNGevity Foundation@LUNGevityScore6060
@TakashiKohno2
Same topic EGFR · 14 peopleHeat 54 likes0 replies1 repost
05:05
Molecular Cancer Therapeutics@MCT_AACRScore6060
Online now! Simultaneous publication with an
Same topic EGFR · 14 people METHeat 11 like0 replies0 reposts

Apr 20Mon

Monday · 4 items

09:40
Ingo Hartung@HartungIngoScore6060
The 3rd day at #AACR26 was again loaded with impressive science. Here are my highlights: Georg Winter‘s proxidrugs plenary, Tango‘s HBS1L...
Same topic EGFR · 14 people ALKHeat 4739 likes0 replies8 reposts
08:26
Jia (Jenny) Liu MD PhD@JiaJennyLiuScore6060
Fascinating ADC clinical trial plenary at #AACR26.
Same topic EGFR · 14 peopleHeat 5742 likes2 replies13 reposts
01:39
Anu R I@anu_irisScore6060
#AACR26
Same topic EGFR · 14 people #CARTTHERAPY #CLINICALTRIAL #GLIOBLASTOMAHeat 11 like0 replies0 reposts
01:30
Cancer Research@CR_AACRScore6060
Lori Friedman, the chairperson for today's New Drugs on the Horizon session at #AACR26, recently published a study describing a novel EGF...
Same topic EGFR · 14 peopleHeat 32 likes0 replies1 repost