Lung cancer: perioperative IO and KRAS NSCLC
Sherlock-Lung’s 1,209 whole genomes: EGFR more often in never-smokers, KRAS more often in smokers.
Fascinating ADC clinical trial plenary at #AACR26.
Across EGFR and CLDN6 ADCs, target IHC expression alone failed to predict efficacy.
We are still selecting patients using a unidimensional biomarker for a multidimensional () drug.
Elegant discussion
@rne_md
Heat 57 · 42 likes · 2 replies · 13 reposts
Neeraj Joshi, Sarah J. Harmych, Hidenori Tanaka, Galina Bogatcheva, Marisol A. Ramirez, Ramona Graves-Deal, Claiborne W. Tydings, Claudia C. Wahoski, Chelsie K. Sievers, Maria Johnson Irudayam, James N. Higginbotham, Frank L. Revetta, Zhiguo Zhao, Jeffrey L. Franklin, Binyam Yilma, Tina M. O'Grady, Stamatina Fragkogianni, Metamia Ciampricotti, M Kay Washington, Xingyi Guo, Allison S. Walker, Jens Meiler, Qi Liu, Robert J. Coffey, Eben L. Rosenthal, Bhuminder Singh
Read the abstract →Ya-Wen Lu, Alexandra Borodovsky, Ge Peng, Karthik Arumugam, Paul L. Auger, Delia Bradford, Lilly G. Carlson, Scott K. Kimura, Daniel Medina-Cleghorn, Mariah J. Mesner, Davorka Messmer, Madeleine P. Nemchek, Ryan B. Rountree, Rusha M. Sardhara, Sangita Sridharan, Jennifer M. Stokes, Leslie Tong, Alexandra M. Trotier, Jennifer S. Tung, Ge Wei, Jeffrey Wu, Jordan Ye, Gwenn M. Hansen.
Read the abstract →Source: Jia (Jenny) Liu MD PhD · x.com