🎥 #OAOnTheGO | #ESMO26 马德里
@OncoAlert
个性化癌症疫苗正从概念走向具有临床意义的信号。
INTerpath-001 结果为阳性。
Dr. @MarioBalsaMD 讨论了在切除后的 #Melanoma 中 pembrolizumab 联合个性化 mRNA 疫苗 V940。
📊 2 年 RFS：82% 对 60%
HR 0.58
📊 DMFS：88.5% 对 80.2%
HR 0.62
🎯 为什么这很重要：这不仅仅是另一项辅助免疫治疗研究。它证明了患者特异性新抗原疫苗能在 PD-1 阻断基础上增加有意义的疾病控制获益。
对我来说，接下来的问题甚至更重要：
🧬 谁获益最大？
⏳ 这能转化为总生存 (OS) 优势吗？
🔄 它应如何相对于新辅助免疫治疗定位？
🎯 生物标志物能否识别真正需要这种程度个性化的患者？
@MarioBalsaMD 的精彩讨论，建立在 @ProfGLongMIA @jasonlukemd 以及 INTerpath-001 研究者的重要工作之上。
🎬 观看来自 @OncoAlert 的最新 #OAOnTheGO。
@DrBetofMDPhD @cdanicas @UOzkerim @DrMirallas @DrYukselUrun @GaiaGriguolo @JankovicK @ElisaAgostinett @to_be_elizabeth @nataliagandur
#OncoAlert #ESMO26 #Melanoma #mRNA #CancerVaccines #Immunotherapy #PrecisionOncology
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INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
https://esmocongress.esmo.orgPerioperative durvalumab with or without tremelimumab plus neoadjuvant enfortumab vedotin in muscle-invasive bladder cancer: Results from the phase 3 VOLGA trial
https://esmocongress.esmo.orgTarlatamab plus durvalumab (durva) vs durva as 1L maintenance (1LM) therapy following durva, platinum, and etoposide (1L durva + EP) in extensive-stage small cell lung cancer (ES-SCLC): Primary analysis of the phase 3 DeLLphi-305 trial
https://esmocongress.esmo.orgDarolutamide with androgen deprivation therapy (ADT) and definitive or salvage locoregional radiation therapy (RT) for localised, very high-risk prostate cancer: Interim analysis of an international, placebo-controlled, randomised phase 3 t
https://esmocongress.esmo.org🎥 #OAOnTheGO | OncoAlert at #ESMO26 Madrid INTerpath-001 is positive! 🔬 @ProfGLongMIA @jasonlukemd Dr. Mario Balsa (@HospitalClínic Barcelona) discusses pembrolizumab + personalized mRNA vaccine V940 in resected melanoma. 📊 2-year RFS: 82% vs 60% (HR 0.58) 📊 DMFS: 88.5% vs 80.2% (HR 0.62) Will this translate into longer survival? Who benefits most? And how does it fit with neoadjuvant immunotherapy? 🎬 Watch now! #Melanoma #OncoAlert @DrBetofMDPhD, @cdanicas, @matteolambe, @NiuSanford, @GlopesMd, @PGrivasMDPhD, @brian_rini, @to_be_elizabeth, @ElisaAgostinett, @nataliagandur, @UOzkerim, @DrMirallas, @DrYukselUrun, @Lucarecco, @mzugman, @HHorinouchi, @p_ciracimd, @DraMartinezLago, @DrVilmaPBarcia, @GIMedOnc, @MarioBalsaMD, @scocmem, @AmandaNizamMD, @GaiaGriguolo, @JankovicK, @Dr_Oncologista, @Erman_Akkus, @WeOncologists, @niklas_kluemper, @Markuseckstein在 X 查看被引用的帖子
来源：Dra. María Natalia Gandur Quiroga · x.com