Cell· Alex C.Y. Chen, Keely Y. Ji, Cansu Yerinde, Nelson H. Knudsen, Kevin Bi, Shumeng Hao, Vasyl Zhabotynsky, Daniela Martinez, Thomas J. Carmona-LaSalle, Kazuhiro Taguchi, Katherine H. Xu, Elizabeth M. Seider, Marc A. Schwartz, Maria Zschummel, Linda T. Nieman, Kathleen B. Yates, Francesca S. Gazzaniga, Brian C. Miller, Thorsten R. Mempel, Robert T. Manguso, Nir Hacohen, Debattama R. Sen·· 2026-07-29评分53
CRISPR筛选鉴定Dusp5与Zfp219为衰老相关T细胞功能障碍的挽救靶点
CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer
导读
CRISPR筛选鉴定Dusp5和Zfp219为衰老相关T细胞功能障碍的关键调控因子，敲除任一基因可驱动T细胞进入效应样状态，通过不同机制改善衰老肿瘤微环境中的肿瘤控制。
来源：Cell · cell.com