🔥🎯 #ESMO26 NADINA,3年更新
新辅助 ipi-nivo 与 手术 + 辅助 nivo 在宏观 III 期 #melanoma 中的对比
➡️ 3年 EFS 72.9% 对 50.0% | HR 0.42
➡️ 3年 DMFS 75.3% 对 57.4% | HR 0.46
➡️ 3年 RFS:pCR 91% | near-pCR 62% | pPR 88% | pNR 43%
➡️ G≥3 TRAEs 32% 对 16%
🔍 结合 INTerpath-001 的热度来读:在宏观 III 期,单用辅助 PD-1 已不再是标准。
‼️:pCR 后约 9% 复发,且 near-pCR(未给辅助)预后比 pPR(给了辅助)更差。1-10% RVT 中是否还有免疫治疗的空间?
🧬 RVT 拥有其自身的免疫生物学特性。
@myESMO @OncoAlert @_SEOM @brunolarvol
#Melanoma
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INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
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https://esmocongress.esmo.orgDarolutamide with androgen deprivation therapy (ADT) and definitive or salvage locoregional radiation therapy (RT) for localised, very high-risk prostate cancer: Interim analysis of an international, placebo-controlled, randomised phase 3 t
https://esmocongress.esmo.orgEmotional distress (ED) upfront neoadjuvant ipilimumab + nivolumab (IPI+NIVO) is associated with lower pathological response and toxicity
https://esmocongress.esmo.orgImpact of BRAF V600K mutation in patients with resectable stage III melanoma: A subgroup analysis of the NADINA trial
https://esmocongress.esmo.org来源:Yago Garitaonaindía · x.com
