VOLGA試験：ctDNAクリアランスと予後
#ESMO2026
MIBCに対するEVデュルバルマブ(D)術前治療の探索解析
① 治療前ctDNA+の60%が陰性化
② ctDNA陰性化は良好なEFSと関連（24mo 81% vs 55%）
③ ctDNA持続+患者は予後不良
ctDNA陰性化は、単にpCRを反映しているのか or pCRとは別の情報を持つのか?
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https://esmocongress.esmo.orgctDNA analysis is an increasingly utilised prognostic tool in muscle invasive bladder cancer. In VOLGA 78% of the muscle invasive bladder cancer patients were ctDNA positive at baseline which was prognostic. Also, the combination of perioperative durvalumab and neoadjuvant EV cleared ctDNA in 60% of patients (using the Natera Genome assay which has increased sensitivity). Clearance was associated with much better outcomes. #ESMO26在 X 查看被引用的帖子
来源：Shingo Hatakeyama · x.com