The 2nd oxadiazole-containing CRBN-dependent molecular glue degrader at #AACR26 today. Triana‘s CNS penetrating oral ALK degrader TRI-611...

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Ingo Hartung· @HartungIngo · X·2026-04-20 06:55· 2026-04-20评分60

TRI-611

解读

小分子药物化学 — CDK2、WEE1、SERD（非 KRAS）

TRI-611 · 会场出现的早期编号

正文 · 机器翻译

今天在 #AACR26 发布的第二款含噁二唑的 CRBN 依赖性分子胶降解剂。Triana 的可穿透中枢神经系统的口服 ALK 降解剂 TRI-611 不作用于 ALK 的 ATP 结合位点，并利用一种新型螺旋型降解子劫持 CRBN，从而实现较高的降解剂选择性。

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会议摘要

4618按代号 TRI-611 对上

TRI-611, a development stage molecular glue degrader of ALK for the treatment of ALK-positive NSCLC including central nervous system metastases

Andrew R. Conery, Daniel S. La, Artyom A. Alekseyenko, David Marcoux, Aaron G. Bart, Matt L. Harlow, Patrick R. Arsenault, Nico R. Cantone, Rebecca L. Casaubon, Hari B. Kamadurai, Aravind Prasad Medikonda, Duncan E. Nunes, Tim J. Wigle, Maolin Yu, Aleksandra Zagulyaeva, Christine Zarate, Kathleen I. Seyb, Patrick Trojer, Vito J. Palombella

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5787按代号 TRI-611 对上

TRI-611, a development stage molecular glue degrader of ALK, promotes the degradation of TKI-resistant ALK fusion proteins and leads to regression of ALK TKI-refractory tumors

Andrew R. Conery, Daniel S. La, Artyom A. Alekseyenko, David Marcoux, Aaron G. Bart, Matt L. Harlow, Patrick R. Arsenault, Nico R. Cantone, Rebecca L. Casaubon, Hari B. Kamadurai, Aravind Prasad Medikonda, Duncan E. Nunes, Tim J. Wigle, Maolin Yu, Aleksandra Zagulyaeva, Christine Zarate, Lauren Highfield, Nobuyuki Kondo, Aaron N. Hata, Kenneth Ngo, Jisu Lee, Prafulla C. Gokhale, Kathleen I. Seyb, Patrick Trojer, Vito J. Palombella

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来源：Ingo Hartung · x.com