在单用 pembrolizumab 的基础上，每100名患者中多12名在2年时仍保持无复发。INTerpath-001（LBA1，#ESMO26）：切除后的 IIB–IV 期黑色素瘤；intismeran autogene + pembrolizumab 对比 pembrolizumab（n=1,137）。
禁运期被突破后提前发布——请在 PS I (Long) 确认。@ProfGLongMIA
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INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
https://esmocongress.esmo.orgINTerpath-001
https://esmocongress.esmo.org- Mustafa Özdoğan, MD@ozdogan_md
Circulating — confirm at PS I (Long). Solid so far: 24-mo RFS 82.2% vs 70.0%, HR 0.58 (0.45–0.75). Absolute +12.2 pp · NNT ≈8 if rates hold. DMFS 88.5% vs 80.2%, HR 0.62. Grade ≥3 AE 23.6% vs 20.3%. Piecewise signal from early release: curves flat ~first 6 months, then HR ~0.42 after immunization. OS immature — that remains the practice-changing ask.
来源：Mustafa Özdoğan, MD · x.com