Cancer Cell· Fei Ji, Lei Zheng, Dapeng Chen, Peng Xia, Zhongyu Zou, Wei Liu, Jason Bugno, Emile Z. Naccasha, András Piffkó, Chuangyu Wen, Kangdi Li, Liping Xu, Sean Z. Luo, Xiaona Huang, Jiaai Wang, Chengwei Ju, Bei Liu, Yiyi Ji, Han Li, Steven J. Chmura, Sean P. Pitroda, Hua Laura Liang, Chuan He, Ralph R. Weichselbaum·· 15 天前精选评分55
放疗通过TET2依赖性表观转录程序诱导髓系细胞产生免疫抑制性M-MDSC
Myeloid reprogramming generates myeloid-derived activating cells to potentiate radiotherapy and suppress metastasis
导读
放疗诱导髓系细胞中TET2依赖性表观转录程序，促进免疫抑制性M-MDSC分化。TET2缺失保留caRNA m5C-MBD6信号传导，恢复IRF3-IFN-I激活，产生髓源性激活细胞，并增强放疗诱导的抗肿瘤免疫。
来源：Cancer Cell · cell.com