Science Translational Medicine· Yuli Chen, Qinnan Chen, Jiahao Guo, Ziwei Li, Shaokun Yu, Peng Huang, Xiao Ke, Xuefei Shi, Ming Sun, Fengqi Nie, Xianghua Liu·· 9 天前精选评分60
SCRMP介导CSNK2B SUMO化促进DNA损伤修复导致小细胞肺癌顺铂耐药
SCRMP-mediated SUMOylation of CSNK2B facilitates DNA damage repair to promote cisplatin resistance in small cell lung cancer
导读
研究发现SCRMP介导的CSNK2B SUMO化修饰通过促进DNA损伤修复导致小细胞肺癌顺铂耐药。机制研究表明CSNK2B SUMO化增强其与DNA修复蛋白的相互作用，敲低SCRMP或抑制CSNK2B可逆转顺铂耐药。DOI: 10.1126/scitranslmed.aea5653。
来源：Science Translational Medicine · science.org