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Yago Garitaonaindía· @YGaritaonaindia · X·· 19 小时前评分45

#MELANOMA

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🔥 #ESMO26 TLND omission after neoadjuvant IO in stage III #melanoma

🎙️ van Akkooi

Many centres already omit TLND with local, non evidence-based strategies outside PRADO.

Two trials will give the answer:

➡️ OMIT (NL): nivo+ipi, ILN MPR → omit TLND
➡️ MSLT-3: randomised ILN-only vs TLND, response-adapted, n≈1,574

@_SEOM @myESMO @oncodaily

#IO

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会议摘要
2071O按 Proffered paper: Melanoma and other skin tumours 对上

STARBOARD phase 3: A randomized, double-blind study of first-line (1L) encorafenib (enco), binimetinib (bini), and pembrolizumab (pembro) vs placebo (pbo) and pembro for unresectable locally advanced or metastatic BRAF V600-mutant melanoma

https://esmocongress.esmo.org
2072O按 Proffered paper: Melanoma and other skin tumours 对上

Efficacy and safety of lifileucel and pembrolizumab in patients with immune check point inhibitor-naïve advanced melanoma: Final results from IOV-COM-202 study

https://esmocongress.esmo.org
2079P按 Melanoma 对上

Transcriptomic and epigenomic profiling of TIL products identifies determinants of clinical benefit in advanced melanoma

https://esmocongress.esmo.org
LBA1按 Presidential Symposium I 对上

INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)

https://esmocongress.esmo.org

来源:Yago Garitaonaindía · x.com

CBACBA Frontier Insights (CFI)美国华人生物医药科技协会(CBA)www.cba-usa.org