Science Translational Medicine· Silvia Coma, Monica Musteanu, Cristina Caffarra Malvezzi, Ryan R. Jamieson, Enrico Patrucco, Alessia Mira, Julien Dilly, Ziyue Li, Ana Fernández-Rodríguez, Alejandra López-García, Andrew J. Aguirre, Mariano Barbacid, Chiara Ambrogio, Jonathan A. Pachter·· 2 天前评分33
FAK抑制剂与RAF/MEK钳合剂avutometinib增强KRAS G12C抑制剂在非小细胞肺癌临床前模型中的疗效
FAK inhibitor and RAF/MEK clamp avutometinib enhance KRAS G12C inhibitor efficacy in preclinical models of non–small cell lung cancer
导读
一项临床前研究显示，FAK抑制剂与RAF/MEK钳合剂avutometinib联用，可增强KRAS G12C抑制剂在非小细胞肺癌模型中的疗效。该研究为KRAS G12C靶向联合治疗策略提供了临床前数据。
来源：Science Translational Medicine · science.org