Cell· Mengyan Wang, Tingting Liu, Qihua Dai, Jialin Teng, Yaping Wu, Jinchao Jia, Jianfen Meng, Yuning Ma, Hui Shi, Xiaobing Cheng, Honglei Liu, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Yue Sun, Yan Wu, Jia Chen, Wei Yin, Peng Gao, Wenjie Song, Rui Lin, Bo Ying, Chengde Yang, Qiongyi Hu·· 14 天前精选评分61
mRNA编码的CD19×CD3 T细胞衔接器在难治性免疫性血小板减少症中实现持续血小板恢复
mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia
导读
mRNA脂质纳米颗粒编码的CD19×CD3 T细胞衔接器在临床前模型中显示出减弱的细胞因子释放和B细胞耗竭能力。在三名难治性免疫性血小板减少症患者中，该治疗实现了超过6个月的血小板持续恢复，表明mRNA编码的T细胞衔接器是B细胞驱动自身免疫性疾病中重置自身反应性免疫的有前景的治疗方法。
来源：Cell · cell.com