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Nieves Martinez Lago MD PhD· @DraMartinezLago · X·· 2 天前评分70

trastuzumab

正文 · 机器翻译

#ESMO26 🧬 KC-WISE | III 期

👥 246 例 | 赫赛汀治疗后 HER2+ 胃癌/胃食管结合部癌
💊 安贝尼单抗 + 化疗 vs 化疗

🚀 OS:19.6 对 9.6 个月 (HR 0.39; p<0.0001)
📈 PFS:7.1 对 2.7 个月 (IRC)
🎯 ORR:56% 对 14%

⚠️ G≥3 TEAEs:74.2% 对 54.5%

💡 显著生存获益,伴随毒性增加。

@OncoAlert

442 浏览 · 8 赞 · 8 转发 · 0 回复

会议摘要
1766RO按 Rapid oral 1: Breast cancer, advanced stage 对上

Health-related quality of life from HER2CLIMB-05: A phase 3 study of tucatinib versus placebo in combination with trastuzumab and pertuzumab as 1L maintenance therapy for HER2+ mBC

https://esmocongress.esmo.org
1780P按 HER2+ breast cancer 对上

Safety, social costs and quality of life (QOL) in HER2-positive (HER2+) breast cancer (BC) patients (pts) treated with pertuzumab + trastuzumab fixed-dose combination subcutaneous (PT FDC SC): The PERTURB study

https://esmocongress.esmo.org
1795TIP按 HER2+ breast cancer 对上

A global, interventional, open-label trial of trastuzumab deruxtecan (T-DXd)–based therapy in first-line HER2-positive metastatic breast cancer: DESTINY-Breast Guide

https://esmocongress.esmo.org
35P按 Advanced breast cancer, other 对上

Comparative effectiveness of trastuzumab deruxtecan versus sacituzumab govitecan in HER2-negative metastatic breast cancer: A real-world analysis with propensity score matching

https://esmocongress.esmo.org
539RO按 Rapid oral: Breast cancer, early stage 对上

Patient-reported outcomes (PROs) from DESTINY-Breast05: Health-related quality of life (HRQoL) with trastuzumab Deruxtecan (T-DXd) versus trastuzumab emtansine (T-DM1) in patients (Pts) with high-risk HER2-positive early breast cancer (eBC)

https://esmocongress.esmo.org
543RO按 Rapid oral: Breast cancer, early stage 对上

DESTINY-Breast11: MRI-assessed objective responses during neoadjuvant treatment (NAT) with trastuzumab deruxtecan (T-DXd) followed by paclitaxel + trastuzumab + pertuzumab (THP) vs dose-dense doxorubicin + cyclophosphamide followed by THP (

https://esmocongress.esmo.org

来源:Nieves Martinez Lago MD PhD · x.com

CBACBA Frontier Insights (CFI)美国华人生物医药科技协会(CBA)www.cba-usa.org