Cancer Cell· Laurine Noblecourt, Amanda Wicki, Ashwin Jainarayanan, Vinnycius Pereira-Almeida, James McAuliffe, Emily Steffke, Silvia Panetti, Hannah Fuchs, Ramiro A. Ramirez-Valdez, Vineethkrishna Chandrasekar, Yanshu Cai, Sanne Boekestijn, Adrian V.S. Hill, Audrey Gerard, Marij J.P. Welters, Sjoerd H. Van der Burg, Isabela Pedroza-Pacheco, Benoit J. Van den Eynde, Carol Sze Ki Leung·· 21 小时前评分31
化疗增强癌症疫苗疗效并扩增干样 TCF1+CD8+ T 细胞
Chemotherapy enhances cancer vaccine efficacy and expands stem-like TCF1+CD8+ T cells
导读
Noblecourt 等发现，化疗在癌症疫苗启动期可充当免疫佐剂，扩增 TCF1+CD8+ 干样 T 细胞，从而增强疫苗诱导的抗肿瘤免疫。该研究为临床上将化疗、癌症疫苗与 PD-1 阻断三者联用提供了依据。
来源：Cancer Cell · cell.com