Moving beyond #ALK TKIs - a first-in-class ALK molecular glue degrader that could change the game in ALK+ #NSCLC #AACR26.

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LUNGevity Foundation· @LUNGevity · X·2026-04-20 09:36· 2026-04-20评分60

TRI-611

解读

小分子药物化学 — CDK2、WEE1、SERD（非 KRAS）

TRI-611 · 会场出现的早期编号

正文 · 原文

Moving beyond #ALK TKIs - a first-in-class ALK molecular glue degrader that could change the game in ALK+ #NSCLC #AACR26.
Why a degrader instead of another TKI? Acquired resistance is inevitable. TRI-611 works differently -> recruits CRBN to degrade ALK protein entirely,

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会议摘要

4618按代号 TRI-611 对上

TRI-611, a development stage molecular glue degrader of ALK for the treatment of ALK-positive NSCLC including central nervous system metastases

Andrew R. Conery, Daniel S. La, Artyom A. Alekseyenko, David Marcoux, Aaron G. Bart, Matt L. Harlow, Patrick R. Arsenault, Nico R. Cantone, Rebecca L. Casaubon, Hari B. Kamadurai, Aravind Prasad Medikonda, Duncan E. Nunes, Tim J. Wigle, Maolin Yu, Aleksandra Zagulyaeva, Christine Zarate, Kathleen I. Seyb, Patrick Trojer, Vito J. Palombella

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5787按代号 TRI-611 对上

TRI-611, a development stage molecular glue degrader of ALK, promotes the degradation of TKI-resistant ALK fusion proteins and leads to regression of ALK TKI-refractory tumors

Andrew R. Conery, Daniel S. La, Artyom A. Alekseyenko, David Marcoux, Aaron G. Bart, Matt L. Harlow, Patrick R. Arsenault, Nico R. Cantone, Rebecca L. Casaubon, Hari B. Kamadurai, Aravind Prasad Medikonda, Duncan E. Nunes, Tim J. Wigle, Maolin Yu, Aleksandra Zagulyaeva, Christine Zarate, Lauren Highfield, Nobuyuki Kondo, Aaron N. Hata, Kenneth Ngo, Jisu Lee, Prafulla C. Gokhale, Kathleen I. Seyb, Patrick Trojer, Vito J. Palombella

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来源：LUNGevity Foundation · x.com