Cell· Li Qiang, Megan T. Hoffman, Jung-Ho Chun, Brendan Parent, Felix Hambitzer, Frank Peprah, Courtney T.S. Kureshi, Birkley S. Lim, Eugena Chang, Michael J. Walsh, Julissa G. Tello, Tavus Atajanova, Hojeong Shin, Corey Perkins, Rakeeb Kureshi, Yaniris Molina-Aponte, James M. Dougan, Chong Zuo, Lauren Brais, Thomas E. Clancy, James M. Cleary, Jason L. Hornick, Brandon M. Huffman, Joseph D. Mancias, George Molina, Mark Fairweather, Jonathan A. Nowak, Kimberly J. Perez, Douglas A. Rubinson, Sarah Slater, Ritchell van Dams, Jiping Wang, Brian M. Wolpin, Kwok-Kin Wong, Harshabad Singh, Andrew J. Aguirre, David Baker, Michael Dougan, Stephanie K. Dougan·· 9 天前精选评分57
CD4 T细胞将KRAS抑制剂的短暂响应转化为胰腺癌的持久缓解
CD4 T cells convert transient responses to KRAS inhibition to durable remissions in pancreatic cancer
导读
一项研究显示，AI设计的IL-21模拟物可通过CD4 T细胞将KRAS抑制剂的短暂响应转化为胰腺癌的持久缓解，且该过程不依赖CD8 T细胞和肿瘤MHC I类表达。
推荐理由
该研究通过AI设计的IL-21模拟物，揭示了CD4 T细胞在胰腺癌中对KRAS抑制剂疗效的转化作用，为克服耐药提供了新视角。
来源：Cell · cell.com