#ESMO26 | POP-DURVA
在 I 期 TNBC 中,评估了单次剂量 durvalumab 不联合化疗的临床和免疫学效果(n=71)。
- pCR:1.7%
- 客观缓解率:11.6%
- 肿瘤缩小:41.3%
- 转化为炎症表型:最初免疫阴性肿瘤的 33%。
单次免疫治疗诱导了显著的免疫激活,但病理反应非常有限。
该研究的主要价值在于识别免疫治疗敏感性的潜在生物标志物,而非证明无化疗方案的疗效。
然而,仅 15 天治疗后的结果无法确立长期单药疗法的疗效。
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https://esmocongress.esmo.org来源:Yakup Ergün · x.com
