跳到正文
Yakup Ergün· @dr_yakupergun · X·· 13 小时前评分70

durvalumab

正文 · 机器翻译

#ESMO26 | POP-DURVA

在 I 期 TNBC 中,评估了单次剂量 durvalumab 不联合化疗的临床和免疫学效果(n=71)。

- pCR:1.7%
- 客观缓解率:11.6%
- 肿瘤缩小:41.3%
- 转化为炎症表型:最初免疫阴性肿瘤的 33%。

单次免疫治疗诱导了显著的免疫激活,但病理反应非常有限。

该研究的主要价值在于识别免疫治疗敏感性的潜在生物标志物,而非证明无化疗方案的疗效。

然而,仅 15 天治疗后的结果无法确立长期单药疗法的疗效。

432 浏览 · 4 赞 · 4 转发 · 0 回复

会议摘要
2879RO按 Rapid oral 1: Gastrointestinal tumour, upper digestive 对上

Durvalumab plus definitive chemoradiotherapy versus definitive chemoradiotherapy in patients with locally advanced esophagus carcinoma: ARION PRODIGE 67 randomized phase 2 trial

https://esmocongress.esmo.org
4737RO按 Rapid oral 1: Genitourinary tumours, renal and urothelial 对上

Durvalumab (D) in Combination With BCG Induction and Maintenance (I+M) for BCG-Naïve, High-Risk Non-Muscle-Invasive Bladder Cancer (NMIBC): Early Recurrence and Cystectomy-Free Survival in Patients (pts) With Papillary Only Tumours From POT

https://esmocongress.esmo.org
LBA2按 Presidential Symposium I 对上

Perioperative durvalumab with or without tremelimumab plus neoadjuvant enfortumab vedotin in muscle-invasive bladder cancer: Results from the phase 3 VOLGA trial

https://esmocongress.esmo.org
LBA26按 Proffered paper 2: Breast cancer, early and advanced stage 对上

Short-term preoperative durvalumab for stage I TNBC: First results from the phase II UNLOCK 14 - POP-DURVA trial

https://esmocongress.esmo.org
LBA3按 Presidential Symposium I 对上

Tarlatamab plus durvalumab (durva) vs durva as 1L maintenance (1LM) therapy following durva, platinum, and etoposide (1L durva + EP) in extensive-stage small cell lung cancer (ES-SCLC): Primary analysis of the phase 3 DeLLphi-305 trial

https://esmocongress.esmo.org
LBA37按 Proffered paper: Gynaecological cancers 对上

Durvalumab (D) plus carboplatin/paclitaxel (CP) followed by D with or without olaparib (O) in advanced/recurrent endometrial cancer (a/rEC): Interim overall survival (OS) and safety from the randomised phase 3 DUO-E/GOG-3041/ENGOT-EN10 stud

https://esmocongress.esmo.org

来源:Yakup Ergün · x.com

CBACBA Frontier Insights (CFI)美国华人生物医药科技协会(CBA)www.cba-usa.org