Genetic and environmental factors shape DNA methylation linked to ADHD in childhood
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A preprint posted to bioRxiv examines how genetic variants and environmental exposures relate to DNA methylation at ADHD-associated CpG sites across childhood and adolescence. In a longitudinal cohort of children aged 9.5 to 11.9, 19 methylation quantitative trait loci (meQTLs) explained up to 40% of methylation variance at five ADHD-associated CpG sites. LASSO regression in 126 children identified 17 environmental predictors of methylation. Household income and school quality of life were associated with declining methylation at specific sites over time, and income showed divergent effects by clinical course: protective in children whose ADHD remitted, and the opposite in those whose ADHD persisted. The work links genetic and environmental influences to epigenetic variation relevant to ADHD trajectories, with further validation still ahead given its preprint status.
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- biorxiv.orgGenetic and environmental factors associated with DNA methylation across childhood and adolescence in individuals with and without attention-deficit/hyperactivity disorder
In a longitudinal cohort of children aged 9.5-11.9 years, 19 meQTLs explained up to 40% of DNA methylation variance at 5 ADHD-linked CpG sites, and LASSO regression in 126 children identified 17 environmental predictors. Household income and school quality of life were associated with declining methylation at specific CpG sites over time, with income showing a protective effect in the remitted ADHD group and the opposite in the persistent group.
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