sacituzumab
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A Merck vice president said sac-TMT, the ADC partnered with Kelun-Biotech, uses an irreversible linker that keeps the drug stable in the blood until it reaches the tumor, with payload release in what he called the 'Goldilocks zone.' The original contrasts this with the reversible linkers of Trodelvy and Datroway, noting that premature payload release can cause anemia and neutropenia, while release that is too slow may also affect other TROP2-expressing tissues.
Excerpted from biospace.com
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- biospace.comPickESMO 2026: Merck’s Kelun-partnered ADC hits the ‘Goldilocks zone,’ VP says
A Merck vice president said sac-TMT, the ADC partnered with Kelun-Biotech, uses an irreversible linker that keeps the drug stable in the blood until it reaches the tumor, with payload release in what he called the 'Goldilocks zone.' The original contrasts this with the reversible linkers of Trodelvy and Datroway, noting that premature payload release can cause anemia and neutropenia, while release that is too slow may also affect other TROP2-expressing tissues.
- mp.weixin.qq.comPickKelun-Biotech TROP2 ADC Sacituzumab Tirumotecan Posts Final TNBC OS, Median OS 14.7 Months
At the ESMO congress, Kelun-Biotech's TROP2 ADC sacituzumab tirumotecan (SKB264) presented the final overall survival analysis of a China trial in second-line and later advanced triple-negative breast cancer. With 29.4 months of follow-up, median OS was 14.7 months versus 9.9 months with chemotherapy, HR=0.60; after adjusting for subsequent ADC treatment as a confounder, HR=0.55.
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Heat now 58·Peak in the comparable set 80 (Oct 25 01:00)·Change over 24h in the comparable set +219%·Participants now 12
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