Medicinal chemistry beyond KRAS: CDK2, WEE1, SERD
zedoresertib · A WEE1-path molecule on the floor
#AACR26
New frontiers in oncology
Zedoresertib+Lunresertib #CCNE1 #FBXW7 #PPP2R1A
Dr.Yap
@UTMDAnderson
ORR 25% if #CCNE1
Ovarian ORR 50% at MTD2, if #CCNE1 60%
31% on trial >16w
Rash, fatigue, N/V
Dr. Moore
@StephensonCC
Optimal dose
@OncoAlert
@AACR
Heat 11 · 6 likes · 1 reply · 4 reposts
Timothy A. Yap, Rahul Aggarwal, Elisa Fontana, Martin Hojgaard, Benedito A. Carneiro, Linda Duska, Patricia LoRusso, Siddhartha Yadav, Stephanie Lheureux, Cara Mathews, Ryan H. Moy, Nehal Lakhani, Mia Weiss, Joan Tymon-Rosario, Gerardo Colon-Otero, Ignacio Garrido-Laguna, Elisabeth K. Lee, Esteban Rodrigo Imedio, Jonathan Wessen, Luke Piggott, Vito Dozio, Noemie Luong, Christophe Mas, Alison M. Schram
Read the abstract →Source: Oriol Mirallas MD · x.com