AACR Annual Meeting 2026

April 17–22, 2026 · San Diego · 2418 items

← Immunotherapy: CAR-T in solid tumors, mRNA vaccines, TCR-T

#MRNA

Clinical trial

3 people · 3 posts · 1 abstract

Personalized mRNA vaccines are simpler on paper: sequence the tumor, build a shot, add a PD-L1 antibody and chemotherapy. MSK’s autogene cevumeran showed responders living more than three times as long as non-responders.

Records

Drug / trial	Readout	Setting
autogene cevumeran#MRNA #PANCREATICCANCER	7 of 8 responders alive at 4–6 years; 2 of 8 non-responders	Resected PDAC · Phase 1; Phase 2 n=260 enrolling
mRNA-4157#MRNA	Melanoma RFS HR 0.44	Moderna / Merck · KEYNOTE-942 Phase 2b

Whether autogene cevumeran’s Phase 2 recreates the responder survival advantage.

Other cases in this chapter

CAR-PRISM20/20 MRD-negative; no progression at 15.3 mo median follow-up
EGFRvIII CAR13 patients: 2 PR, 7 SD
局部 nivolumabOral pre-cancer clinical response 85%, 1-year clearance 82%

Evidence

CT122

First-in-human (FIH) study of EVM16, a personalized mRNA neoantigen vaccine, as monotherapy and combination with tislelizumab in advanced solid tumors

Tong Xie, Jian Zhang, Yanchun Meng, Xu Jia, Yue Fan, Li Wang, Jennifer Yang, Sandra Zeng, Hongxia Wang, Lin Shen

Read the abstract →

Floor

Apr 20Mon

Monday · 2 items

03:00
Jyves94@jyves94Score6060
An mRNA-based #mRNA vaccine to prevent #PancreaticCancer from returning shows promising results in a group of 16 patients.
Same topic #MRNA · 3 people #PANCREATICCANCERHeat 64 likes0 replies2 reposts
02:15
Memorial Sloan Kettering Cancer Center@MSKCancerCenterScore6060
An experimental, personalized vaccine using #mRNA to prevent #pancreaticcancer from returning after surgery continues to show promise in ...
Same topic #MRNA · 3 people #PANCREATICCANCERHeat 525392 likes17 replies116 reposts

Apr 19Sun

Sunday · 1 items

00:17
Jason Luke, MD, FACP, FASCO@jasonlukemdScore6060
Super excited for #AACR26 & The Checkpoints gig
Same topic #MRNA · 3 peopleHeat 97 likes0 replies2 reposts