Jason Luke, MD, FACP, FASCO· @jasonlukemd · X·· 2026-04-19Score60
Reading
Immunotherapy: CAR-T in solid tumors, mRNA vaccines, TCR-T
Personalized mRNA vaccines are simpler on paper: sequence the tumor, build a shot, add a PD-L1 antibody and chemotherapy. MSK’s autogene cevumeran showed responders living more than three times as long as non-responders.
Body
Super excited for #AACR26 & The Checkpoints gig
@AACR
annual reception! Let’s enjoy the science then dance it out Sunday night!
@StrandTx
is rapidly moving our #mRNA repRNA & circRNA platforms into clinic to help patients with solid tumors & in vivo CART for hem/autoimmunity!
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Conference abstracts
CT122matched by 药名 tislelizumab
First-in-human (FIH) study of EVM16, a personalized mRNA neoantigen vaccine, as monotherapy and combination with tislelizumab in advanced solid tumorsTong Xie, Jian Zhang, Yanchun Meng, Xu Jia, Yue Fan, Li Wang, Jennifer Yang, Sandra Zeng, Hongxia Wang, Lin Shen
Read the abstract →Source: Jason Luke, MD, FACP, FASCO · x.com