#ESMO26 @niazi_Dr7 DASL-HiCaP (ANZUP1801)
n=1,106 | mFU 3.8 yrs | 85% definitive RT
darolutamide + ADT + RT v placebo + ADT + RT
MFS-CI ➡️ HR 0.42 (0.27–0.66)
4-yr MFS 95% vs 88%
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INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
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https://esmocongress.esmo.orgDarolutamide with androgen deprivation therapy (ADT) and definitive or salvage locoregional radiation therapy (RT) for localised, very high-risk prostate cancer: Interim analysis of an international, placebo-controlled, randomised phase 3 t
https://esmocongress.esmo.org🚨📣📣 #ESMO26 presidential: @niazi_Dr7 Adding darolutamide to ADT + RT dramatically ⬇️ risk of metastasis or death in high-risk localized prostate cancer. Phase 3 DASL-HiCaP = 58% ⬇️ in MFS (HR 0.42) + early OS signal (HR 0.88). #ProstateCancer #RadOnc #pcsm @ChrisSweens1在 X 查看被引用的帖子
来源：Nat Lester-Coll, MD · x.com