DB09では、T-DXd+pertuzumabに内分泌療法の維持療法をした方が13%程度いました。一部は、T-DXd+pertuzumab+内分泌療法だったのかもしれません。
でも、この内分泌療法の上乗せ効果は、前向き試験では示されていません。
今のところは患者さんにお勧めはし難い気持ち。
#ESMO26
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Health-related quality of life from HER2CLIMB-05: A phase 3 study of tucatinib versus placebo in combination with trastuzumab and pertuzumab as 1L maintenance therapy for HER2+ mBC
https://esmocongress.esmo.orgSafety, social costs and quality of life (QOL) in HER2-positive (HER2+) breast cancer (BC) patients (pts) treated with pertuzumab + trastuzumab fixed-dose combination subcutaneous (PT FDC SC): The PERTURB study
https://esmocongress.esmo.orgDESTINY-Breast11: MRI-assessed objective responses during neoadjuvant treatment (NAT) with trastuzumab deruxtecan (T-DXd) followed by paclitaxel + trastuzumab + pertuzumab (THP) vs dose-dense doxorubicin + cyclophosphamide followed by THP (
https://esmocongress.esmo.org来源:tatsunori_shimoi 下井辰徳 · x.com
