Cell· Rosa Delgado Jiménez, Alexandria Ruggles, Mujeeb Adekunle Adedokun, Adam Sorbie, Diana Fink, Samuele Laudani, Alba Simats, Yufei He, Vanessa Pahl, Laura Díaz-Marugán, Morten Voss, Kartikeya Singh, Miquel Lledós, Olga Carofiglio, Philip Melton, Kelsey Pinkham, Alessio Ricci, Stefan Roth, Rebecca Sadler, Svetlina Khayat, Seyedeh Maryam Mousavi, Thanos Tsaktanis, Ann-Marie Tobinski, Carolin Walter, Caspar Ohnmacht, Jochen Huehn, Johannes Herkel, Antonella Carambia, Luisa Klotz, Mathias Gelderblom, Veit Rothhammer, Tommy Regen, Jürgen Bernhagen, Michael Gigl, Michael Zimmermann, Israel Fernandez-Cadenas, Lorenz Hirt, Michael Delacher, Arthur Liesz, Corinne Benakis·· 3 天前精选评分56
肠道菌群通过树突状细胞AHR信号通路加重缺血性脑卒中
Gut microbiota primes stroke severity via the AHR in intestinal dendritic cells
导读
产吲哚大肠杆菌通过激活树突状细胞中的芳烃受体信号通路加重缺血性脑卒中。限制树突状细胞中的AHR信号可促进肠道来源树突状细胞向脑膜迁移，扩增脑膜调节性T细胞，并减轻神经炎症。这一微生物-AHR轴是一个有前景的治疗靶点。
推荐理由
研究揭示了肠道菌群通过树突状细胞AHR信号通路调控脑卒中严重程度的机制，为干预神经炎症提供了新靶点。
来源：Cell · cell.com