ADC 下一代 — 载荷创新
载荷创新是这一届 ADC 的 field-level 方向，不是又开一条赛道。T-DXd 已经在改一线标准；DAC 的临床还薄——Prelude 的 SMARCA2 降解剂单药缓解大约 15%，要从概念走到能卖，数字还差一截。
阅读 @CD_AACR 论文，该论文在 Sarat Chandarlapaty 的 #AACR26 报告中被提及，主题为抗 HER2 ADC 的耐药性：Trastuzumab Deruxtecan (T-DXd) 因 HER2 表达及结合能力丧失而产生耐药性 https://t.co/vvwGdCXUTO @MSKCancerCenter https://t.co/Hlv4cM7qG7
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