Cell· Alexander Maman, Yuko Nobe, Kristin A. Fluke, Katrin Weidenbach, Alexandra N. Harte, Brett W. Burkhart, Jakub Nowak, Priyadarshini Mukherjee, Deepak Kumar Choudhary, Anatoly Kustanovich, Ronit Nir, Katharina Vogl, Kiall Suazo, Danijela Radovanović, Donna Matzov, Walter Rossmanith, Jordan L. Meier, Moran Shalev-Benami, Dina Grohmann, Kylie D. Allen, Eric Westhof, Sebastian Glatt, Ruth A. Schmitz, Thomas J. Santangelo, Masato Taoka, Schraga Schwartz·· 15 天前精选评分35
RNA磷酸骨架表观转录组学：天然RNA硫代磷酸酯及其写入机制的发现
Phosphate backbone epitranscriptomics: Discovery of natural RNA phosphorothioates and their writer machinery
导读
研究在厌氧古菌中发现了天然RNA硫代磷酸酯，这是一种RNA磷酸骨架的立体特异性修饰，将表观转录组的范围扩展到了碱基和核糖修饰之外。Esti酶将这些修饰安装于保守的rRNA和tRNA热点区域，这些对环境敏感的标记能稳定tRNA并在高温下支持细胞生长。
来源：Cell · cell.com