🚨 #ESMO26 | III 期 INTerpath-001 🚨
在摘要提前泄露后，@myESMO 将摘要发布时间提前了!!!!!
没错，结果明确呈阳性：
📉 RFS HR 0.58
📉 DMFS HR 0.62
但令人不安的是：SWOG S1801 也报告了 HR 0.58……只不过是把 3 剂 pembrolizumab 调整到手术之前……
☝🏼人群不同。终点不同。不能进行跨试验比较。
不过话说回来，在 2026 年，个体化 mRNA 疫苗真的应该以辅助治疗 pembro 单药作为对标基准吗？
在称其为新标准之前，我想看到这款疫苗正面对上 NEOADJUVANT 时代。
相同的 HR。不同的路径。而这或许才是 INTerpath 真正的问题 👀
@OncoAlert @OncoReporte @myESMO @_SEOM @GrupoMelanoma
你们怎么看？ @SuyogCancer @OncBrothers @A_May_MD @Dr_R_Kurzrock
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INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
https://esmocongress.esmo.orgINTerpath-001
https://esmocongress.esmo.org- Roberto C. Montoya@roverome
@MarioBalsaMD @myESMO Agree, not the new standard, like many other oncology trials, by the time the result arrives, the comparator is outdated
- Tim M@TJMeehan1
Glad to see melanoma specialists saying it. NADINA and SWOG S1801 already showed starting immunotherapy before surgery beats adjuvant-only, so an adjuvant-only control answers yesterday's question. Same pattern as Moderna's mRNA flu trial in older adults, which compared against standard-dose vaccine instead of the high-dose or adjuvanted shots CDC prefers for 65+. Before payers cover a personalized mRNA product, it should beat today's best option, not an outdated one.
- Dr. Ole Olsen@oolsen50
@MarioBalsaMD @myESMO In both trials RFS with pembro alone about 70% add vax improves to 82%, huge. The HR of 0.58 is the improvement over pembro alone when you add vax.
- Nicholas Hornstein@GIMedOnc
@MarioBalsaMD @KolPulseAI @myESMO I don’t think the neoadjuvant comparison is uncomfortable. Treatment paradigms change over time, in this setting the study crushed it.
- Mario Balsa@MarioBalsaMD
@RyanAugustinMD @myESMO Thank you Ryan! We're on the same page
- Ryan C. Augustin@RyanAugustinMD
@MarioBalsaMD @myESMO Agree, need NADINA style comparative/control, especially with opportunity for path response adaptation. But great proof of concept and AEs aren’t too concerning.
- Mario Balsa@MarioBalsaMD
@GIMedOnc @KolPulseAI @myESMO I didn’t say otherwise. Quite literally the opposite. Read the post again once, twice, or three times if needed.
- Nicholas Hornstein@GIMedOnc
@MarioBalsaMD @KolPulseAI @myESMO Disagree. Technology clearly worked. Future applications are enormous.
来源：Mario Balsa · x.com