Three HER2 ADCs now in HER2-low MBC. At #ESMO26, HORIZON-Breast06 & APEX-Breast01 both beat chemo on PFS (HR ~0.25–0.29). But as @BarbaraPistill2 noted: same payload class as T

Carmen Criscitiello· @CarmenCriscit · X·2026-10-23 20:57· 2 天前评分70

正文 · 机器翻译

目前有三款 HER2 ADC 布局于 HER2-low MBC。在 #ESMO26，HORIZON-Breast06 & APEX-Breast01 在 PFS 上均优于化疗（HR ~0.25–0.29）。但正如 @BarbaraPistill2 所指出的：与 Tdxd 属于相同的载荷类别；对照的是化疗，而非标准治疗。需要开展 ADC 之间的头对头试验。#ESMOAmbassadors @myESMO

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会议摘要

LBA13按 Proffered paper 1: Breast cancer, early and advanced stage 对上

Trastuzumab rezetecan (SHR-A1811) in HER2-low advanced breast cancer (BC): A randomized, phase 3 study (HORIZON-Breast06)

https://esmocongress.esmo.org

来源：Carmen Criscitiello · x.com