Molecular Cell· Benjamin I. Ferman, Chloe Azadegan, John Santoro, Anushka Udara, Madison A. Lineberger, William Lautert-Dutra, Ethan Sumner, Logan McCullough, Erin O’Donnell, Kashish Chetal, Jade Wilson, Zach Gray, Manna Ahmed, Zhijie Deng, Yan Xiong, H. Umit Kaniskan, Damayanti Chakraborty, Thomas L. Clarke, Sedona E. Murphy, Martin Walsh, Alfonso Bellacosa, Hayan Lee, Jian Jin, Capucine Van Rechem, Michael S. Lawrence, Ruslan I. Sadreyev, Johnathan R. Whetstine·· 21 小时前评分46
表观遗传程序决定 MYC 扩增动态并促发瞬时、染色体外及可遗传基因组事件
An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events
导读
Ferman 等人证明表观遗传失衡直接控制 MYC 癌基因扩增动态，为侵袭性肿瘤提供了潜在生物标志物与治疗靶点。当细胞死亡检查点失效时，低拷贝数 MYC 扩增可扩展为高水平扩增，涵盖环状（染色体外）与整合事件，并与肿瘤发生相关。
来源：Molecular Cell · cell.com