Stephanie Graff, MD, FACP, FASCO· @DrSGraff · X·· 1 天前评分70
正文 · 机器翻译
FINER 表明，ipatasertib + fulvestrant 可改善 ITT 和 AKT 通路改变队列的 PFS（但不能改善 OS），并伴有值得注意的 AEs
#ESMO26 @OncoAlert
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会议摘要
LBA14按 Proffered paper 2: Breast cancer, early and advanced stage 对上
A double-blind placebo controlled randomized phase III trial of fulvestrant and ipatasertib as treatment for HER-2 negative and estrogen receptor positive (ER+) metastatic breast cancer (MBC): Overall survival results of the CCTG/BCT MA.40/
https://esmocongress.esmo.org帖内回复
- Ziad Storyteller@AIZiadSaliba
@DrSGraff @OncoAlert I think the signal is in the AKT pathway-altered cohort (HR 0.55), and the cfDNA stratification is the methodologically interesting part. Median PFS ~5.5 months with 92.7% diarrhea and 16.9% grade 3 is a hard trade post-CDK4/6i #ESMO26
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