Science· Hao Zhang, Rabindra V. Shivnaraine, Lu Ren, Phung N. Thai, Remi Janicot, Wenjuan Zhu, Rihua Huang, Dirk H. Siepe, Chengyi Tu, Wenqiang Liu, Marcin Maziarz, Jonathan C. Deutsch, Yu Liu, Chun Liu, Danielle H. Shin, Hyeonyu Kim, Mark Chandy, Marian Kalocsay, Nipavan Chiamvimonvat, Mikel Garcia-Marcos, Brian K. Kobilka, Joseph C. Wu·· 8 天前评分29
Targeting an atypical G protein–coupled receptor signaling pathway for cardiac fibrosis therapy
Targeting an atypical G protein–coupled receptor signaling pathway for cardiac fibrosis therapy
导读
研究揭示了一种非典型 G 蛋白偶联受体信号通路在心脏纤维化中的关键作用，并验证了靶向该通路可有效逆转小鼠模型中的纤维化病理改变。这一发现为开发治疗心脏纤维化的新型疗法提供了潜在靶点。
来源：Science · science.org