🚨 #ESMO2026 | PANKU-Lung01
在EGFR-TKI治疗后的NSCLC中,EGFR×HER3双特异性ADC iza-bren与化疗的对比:
✅ ORR:60.2% vs 34.5%
✅ DoR:10.4 vs 5.7个月
⚠️ ≥3级TRAEs:78.7% vs 62.1%
疗效前景 promising,但毒性仍是挑战。
#LungCancer @OncoAlert @myESMO
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Phase II study of izalontamab brengitecan (Iza-bren) plus osimertinib in patients with EGFR mutant locally advanced or metastatic non-small cell lung cancer (NSCLC)
https://esmocongress.esmo.orgEarly clinical evidence of VRN110755: A novel brain-penetrant EGFR TKI active across common, uncommon, and resistance EGFR mutations
https://esmocongress.esmo.orgEnozertinib (ORIC-114), a brain penetrant, highly selective EGFR inhibitor, in treatment-naive metastatic NSCLC with EGFR atypical mutations
https://esmocongress.esmo.orgTelisotuzumab adizutecan (temab-A) for EGFR-mutated (mut) nonsquamous non-small cell lung cancer (NSQ NSCLC): Post hoc analysis from a phase 1 first-in-human (FIH) study in patients (pts) with brain metastases (BMs)
https://esmocongress.esmo.orgOsimertinib (osi) rechallenge after interstitial lung disease (ILD) during osi treatment (tx) in EGFR-mutated advanced non-small cell lung cancer (NSCLC): A retrospective chart review study
https://esmocongress.esmo.orgDose modifications to manage adverse events (AEs) in 1L EGFR-mutated advanced NSCLC: Post hoc, exploratory analyses from the phase 3 MARIPOSA trial
https://esmocongress.esmo.org来源:OsmanKostekMD · x.com
