The Lancet· Cinta Moraleda, Alfredo Tagarro, Sara Domínguez-Rodríguez, Victor Musiime, Hilda Mujuru, Chishala Chabala, Tisungane Mvalo, Pui-Ying Iroh-Tam, Justina Bramugy, Lola Madrid, Jahit Sacarlal, Alfeu Passanduca, Muhammad Sidat, Uneisse Cassia, Hellen Tukamuhebwa Aanyu, Abner Tagoola, Constantine Mutata, Bwendo Nduna, Chimwemwe Chawinga, Lughano Ghambi, Matthew Bates, Sheila Fernández-Luis, Amir Seni, Merunissa Gafur, Damalie Nalwanga, Denis Nansera, Mutsa Bwakura-Dangarembizi, Natasha Namuziya, Franklyn Nkongho Egbe, John Tembo, Álvaro Ballesteros, Raoul Moh, Lilit Manukyan, David Lora, Olivier Marcy, Tom G Jacobs, David Burger, Quique Bassat, Valeriane Leroy, Alessandra Nardone, W Chris Buck, Pablo Rojo, Empirical Clinical Trial Group·· 2026-07-18评分49
[Articles] 在非洲因重症肺炎住院的HIV感染婴儿中经验性使用缬更昔洛韦：一项多中心、开放标签、析因、随机、对照、优效性试验
[Articles] Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial
导读
在非洲因重症肺炎住院的HIV感染婴儿中，经验性使用缬更昔洛韦与仅接受标准治疗或标准治疗加经验性结核治疗相比，显示出更低的死亡风险。该多中心、开放标签、析因、随机、对照、优效性试验发现，缬更昔洛韦治疗相关的危害证据很少。
来源：The Lancet · thelancet.com