ADC 下一代 — 载荷创新
载荷创新是这一届 ADC 的 field-level 方向，不是又开一条赛道。T-DXd 已经在改一线标准；DAC 的临床还薄——Prelude 的 SMARCA2 降解剂单药缓解大约 15%，要从概念走到能卖，数字还差一截。
在今天的#AACR26临床试验全体会议上：
@DanaFarber
的 Elizabeth Lee 博士报告了一项1期研究的可喜结果，该研究探索了联合使用 trastuzumab deruxtecan 和 olaparib 治疗 HER2 表达阳性的晚期恶性肿瘤（包括卵巢癌）时降低毒性的方法
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读摘要原文 →来源：Dana-Farber News · x.com