PANKU-Breast01 at #ESMO26: izalontamab brengitecan, an EGFR×HER3 bispecific ADC, doubled PFS vs physician's-choice chemo in pretreated HR+/HER2- MBC (8.2 vs 4.0 mo, HR 0.41). A new

Carmen Criscitiello· @CarmenCriscit · X·2026-10-23 21:35· 2 天前评分70

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PANKU-Breast01 at #ESMO26: izalontamab brengitecan, an EGFR×HER3 bispecific ADC, doubled PFS vs physician's-choice chemo in pretreated HR+/HER2- MBC (8.2 vs 4.0 mo, HR 0.41). A new target pairing after CDK4/6 - promising, though a Chinese-only population. #ESMOAmbassadors @myESMO

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LBA50按 Proffered paper 1: Breast cancer, early and advanced stage 对上

PANKU-Breast01: Randomized phase III study of izalontamab brengitecan (iza-bren) in previously treated unresectable locally advanced or metastatic (LA/M) hormone receptor-positive/HER2-negative (HR+/HER2-) breast cancer (BC)

https://esmocongress.esmo.org

来源：Carmen Criscitiello · x.com