Nature Genetics· Katherine A. Kentistou·· 7 天前评分45
Genome-wide mapping of common and rare variant effects on adiposity across childhood
Genome-wide mapping of common and rare variant effects on adiposity across childhood
导读
全基因组分析识别出与儿童期肥胖相关的常见和罕见变异，其中ADCY3、CALCR、MC4R、MRAP2、POMC和MYH13基因的罕见蛋白编码变异在儿童中表现出比成人更强的效应。这些发现揭示了儿童肥胖的遗传基础存在独特的年龄特异性模式。
来源：Nature Genetics · nature.com